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One-carbon metabolism nutrients and polygenic risk scores in relation to breast cancer risk: A nested case-control study within the EPIC cohort
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DOI：10.1016/j.ajcnut.2026.101456.png)
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Abstract
En 中文
One-carbon metabolism (1CM) regulates critical processes to carcinogenesis. However, the influence of 1CM-related nutritional and genetic factors on breast cancer (BC) risk remains unclear.
Keywords:
Dietary intake
EPIC
breast cancer
risk
one-carbon metabolism
B-vitamins
polygenic risk score
nutritional score
BC
breast cancer
BMI
body mass index
CI
confidence interval
DNA
desoxyribonucleic acid
EPIC
European Prospective Investigation into Cancer and Nutrition
ER
estrogen receptor
eQTL
expression-quantitative-trait-loci
FTP
full-term pregnancy
GTEx
Genotype-Tissue Expression Portal
HR
hormone receptor
ICD-O-3
International Classification of Diseases for Oncology (3rd version)
IARC
International Agency for Research on Cancer
LD
linkage disequilibrium
LRT
Likelihood Ratio test
MAF
minor allele frequency
NES
normalized effect size
OR
odds ratio
PR
progesterone receptor
PRS
polygenic risk score
RR
relative risk
SD
standard deviation
U.S.
United States of America
VITAL
VITamins And Lifestyle
1CM
one-carbon metabolism.
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