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OpenFISH enables same-section spatial transcriptomics and MALDI-MSI integration

delete2026-09-29
delete0
PRE
AI
X
Xinyang Li
Y
Yuan Huang
S
Shuo Wang
Y
Ya Li
F
Fengting Jiang
J
Jiawei Gao
Y
Yaran Yang
Q
Qing-Feng Wu
W
Woo-ping Ge
L
Lihui Duan *
DOI：10.1016/j.neuron.2026.09.007delete
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Abstract

Abstract

En 中文
• OpenFISH is an open-source, cost-effective ST platform at single-cell resolution • OpenFISH enables same-section spatial transcriptomics and MALDI-MSI integration • OpenFISH resolves cell-type-associated and compartment-level metabolic patterns • Exploratory 5xFAD analysis reveals cell-type-resolved metabolic alterations
Keywords:
spatial multi-omics
transcriptomics
metabolomics
neurodegenerative disease
neurodevelopment
neuroinflammation

Journal

Neuron cover
Neuron
IF:
15
Papers:
1.4W
Citations:
9.9W

Organization

C
chinese institute for brain research
Scholars:
14
Papers: 13
Citations: 0
C
Chinese Academy of Sciences
Scholars:
1.0W
Papers: 2.9K
Citations: 0
Cited Papers

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