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Opioid-free versus opioid-based anesthesia for postoperative nausea and vomiting in laparoscopic cholecystectomy: A Systematic Review with Meta-Analysis, Meta-Regression and Trial Sequential Analysis

delete2026-05-27
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PRE
AI
J
João Paulo Aureliano de Carvalho *
P
Pablo de Souza Ferreira
E
Elias Batista da Silva Neto
H
Helen dos Reis Requião
L
Liana Maria Tôrres de Araújo Azi
N
Norma Sueli Pinheiro Módolo
R
Rodrigo Leal Alves
DOI:10.1016/j.accpm.2026.101860delete
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Abstract

Abstract

En 中文
• Opioid-free anesthesia reduces postoperative nausea and vomiting after cholecystectomy. • Provides better early postoperative pain control and less need for rescue analgesia. • Associated with lower incidence of intraoperative hypotension compared with opioids. • Maintains safety without increasing bradycardia or postoperative opioid consumption.
Keywords:
Opioid-free anesthesia
Postoperative nausea and vomiting
Laparoscopic cholecystectomy
Pain control
Intraoperative hypotension

Journal

A
Anaesthesia Critical Care & Pain Medicine
IF:
4.7
Papers:
114
Citations:
0

Organization

S
são paulo state university
Scholars:
759
Papers: 223
Citations: 0
F
Federal University of Bahia
Scholars:
327
Papers: 113
Citations: 0
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