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Optimizing protein-cell separation in submerged membrane bioreactor for clarification
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DOI：10.1016/j.memsci.2025.124697.png)
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Abstract
En 中文
• Fractional factorial design (FFD) reveals complex multi-parameter fouling interactions. • Yeast concentration dominates flux decline through cake layer formation. • BSA exhibits dual functionality as both foulant and flux modifier. • Optimal backwashing (BW) achieves 20–25 % flux and BSA transmission gain. • Concentration-independent BSA transmission enables high-titer bioprocessing.
Keywords:
Membrane bioreactor (MBR)
Membrane fouling
Backwashing (BW)
Protein-cell separation
Process intensification
Fractional factorial design (FFD)
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