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Optimizing Subjective Cognitive Decline to Detect Early Cognitive Dysfunction
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DOI：10.3233/JAD-201322.png)
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Abstract
En 中文
Background: The utility of subjective cognitive decline (SCD) as an indicator of preclinical AD is overshadowed by its inconsistent association with objective cognition. Objective: This study examines if manipulations of SCD measurement affect its association with early cognitive dysfunction characteristic of preclinical AD. Methods: Cognitively healthy older adults (n = 110) completed SCD questionnaires that elicited complaints in general, compared to 5 years ago (retrospective SCD) and compared to their peers (age-anchored SCD) in binary and Likert scales. Outcome cognitive tasks included an associative memory task (Face-Name Test), a visual short-term memory binding task (STMB test), and a clinical neuropsychological list learning test (Selective Reminder Test). Results: SCD complaints, when compared to age-matched peers (age-anchored SCD) were endorsed less frequently than complaints compared to 5 years ago (retrospective SCD) (p < 0.01). In demographically adjusted regressions, age-anchored ordinal-rated SCD was associated with short term memory binding (beta = -0.22, p = 0.040, CI = -0.45, -0.01), associative memory (beta = -0.26, p = 0.018, CI = -0.45, -0.06), and list learning (beta = -0.31, p = 0.002, CI = -0.51, -0.12). Retrospective and general ordinal-rated SCD was associated with associative memory (beta = -0.25, p = 0.012, CI = -0.44, -0.06; beta = -0.29, p = 0.003, CI = -0.47, -0.10) and list learning only (beta = -0.25, p = 0.014, CI = -0.45, -0.05; beta = -0.28, p = 0.004, CI = -0.48, -0.09). Conclusion: Ordinal age-anchored SCD appears better suited than other SCD measurements to detect early cognitive dysfunction characteristic of preclinical AD.
Keywords:
Cognitive dysfunction
measurement
neuropsychological tests
preclinical Alzheimer's disease
subjective cognitive decline
task-specific factors
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