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Orchestrating the signaling-bias at the protease-activated receptor, PAR1
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DOI：10.1016/j.tcb.2026.06.004.png)
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Abstract
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The protease-activated receptor-1 (PAR1) exhibits biased agonism upon activation by the coagulant protease thrombin and the anticoagulant protease activated protein C. In a recent study, Gonzalez Ramirez et al. demonstrate that differences in receptor conformations, engagement of G protein-coupled receptor kinase 5, and receptor phosphorylation patterns govern the biased agonism at PAR1.
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