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Organoid modeling of lung branching morphogenesis and epithelial lineage specification
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DOI：10.1016/j.devcel.2026.05.012.png)
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Abstract
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• A chemically defined culture system generates multilevel branching lung organoids (BLOs) • BLOs recapitulate proximodistal patterning and lung epithelial lineage specification • Live imaging reveals branching dynamics of BLOs • BLO-derived cells engraft injured lungs and ameliorate bleomycin-induced fibrosis
Keywords:
lung organoids
branching morphogenesis
proximal-distal patterning
epithelial lineage specification
regeneration
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