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Oscillatory and behavioral indices of cognitive control dysregulation in young adult binge drinkers are influenced by sex differences
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DOI：10.1111/acer.70252.png)
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Abstract
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Background Binge drinking, defined as episodic alcohol intake reaching intoxication, is prevalent among young adults and linked to impaired cognitive control and risk for alcohol use disorder (AUD). Even though executive deficits contribute to addiction, evidence on their alterations in young adult binge drinkers (BDs) as a function of biological sex remains limited. This study examined cognitive and motor aspects of decision making as reflected in event-related theta and beta oscillations, respectively. The executive neurobehavioral markers were analyzed in conjunction with alcohol-related and other self-reported variables and cognitive functions in BDs versus light drinkers (LDs) of both sexes.Methods Sixty-eight participants (34 BDs, 34 LDs, 50% women) completed a modified Stroop task. Electroencephalography (EEG) signals were analyzed in the time-frequency domain with Morlet wavelets. Behavioral performance and event-related theta (4-7 Hz) and beta (15-25 Hz) power were compared across levels of conflict, drinking groups, and sex.Results BDs exhibited longer reaction times on high-conflict trials, reflecting compensatory slowing during cognitive interference. Lower conflict-induced theta power in BDs than in LDs was evident primarily among women. It was associated with greater alcohol intake and it mediated the impact of binge drinking on degraded task performance among BD women. In contrast, event-related beta desynchronization during response preparation was attenuated and delayed only in BD men, which was partially mediated by impulsivity.Conclusions The observed links between binge drinking and dysregulated cognitive and motor control processes were interpreted in regard to sex-specific neural alterations. Weaker engagement of cognitive control in BD women may be reflected in an impaired capacity to optimize decisions in challenging situations. Beta decrease during response preparation was especially attenuated in more impulsive BD men, which may contribute to their inability to refrain from risky behaviors. These findings highlight the need to consider biological sex in alcohol-related neurocognitive research.
Keywords:
binge drinking
event-related beta
event-related theta
sex differences
Stroop task
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