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Overcoming the gastrointestinal mucus barrier: Zinc-dependent modulation of mucinase activity
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DOI：10.1016/j.ijpharm.2025.126445.png)
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Abstract
En 中文
• StcE, a bacterial mucinase, shows promise for transiently disrupting mucus barriers to enhance drug diffusion. • Mucolytic activity of StcE varies across porcine mucus samples, despite preserved enzyme integrity. • Zinc supplementation improves StcE function in degradation resistant mucus. • Cofactor availability, not degradation or inhibition, appears to be a determinant of StcE efficacy in mucus.
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