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Overexpression of miR-455-3p enhances mitophagy, synaptic and mitochondrial proteins in Alzheimer’s disease
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DOI：10.1016/j.mito.2026.102151.png)
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Abstract
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• Reddy lab recently discovered molecular links between miR-455-3p and Alzheimer’s disease. • MicroRNA (miR)-455-3p is known to regulate APP expression, thereby influencing amyloid beta (Aβ) generation. • Reddy lab generated miR-455-3p transgenic (TG), knockout (KO) mice and double mutant mice – 455-3p TG X hAbKI, and miR-455-3p KO X hAbKI. • miR-455-3p TG mice displayed an extended lifespan, whereas miR-455-3p KO mice had a reduced lifespan. • miR-455-3p overexpression enhances mitophagy, mitochondrial biogenesis, dynamics proteins and spine density, in hAbKI mice. • Depleted miR-455-3p exacerbates mitochondrial defects, defective mitophagy and synaptic loss in hAbKI mice.
Keywords:
miR-455-3p
Alzheimer’s disease
mitophagy
mitochondrial dynamics
synaptic density
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