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Oxygen and TGF-β1 jointly regulate fibronectin and trophoblast behavior highlighting a potential role for matrix signalingin severe preeclampsia
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DOI：10.1016/j.matbio.2026.01.002.png)
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Abstract
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• Oxygen tension reshapes how trophoblasts interpret TGF-β1 signaling. • Combined O₂-TGF-β1 control determines fibronectin abundance and assembly. • Fibronectin-integrin engagement regulates invasion and endothelial-like behavior. • Hypoxia disrupts this signaling–matrix axis in severe preeclampsia tissue. • Findings reveal fibronectin as an instructive determinant of trophoblast fate.
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