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Oxygen exposure and diffusion are key formulation barriers in the microencapsulation of extremely oxygen-sensitive next-generation probiotics
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DOI:10.1016/j.jconrel.2026.115208.png)
Abstract
En 中文
• EOS probiotics are not compatible with conventional aerobic bioencapsulation workflows. • Oxygen exposure during homogenisation, aerosolisation, and cross-linking limits EOS viability. • Calcium exposure imposes an additional non-oxygen stress on EOS recovery. • Alginate microcomposites slow oxygen ingress in a particle-size-dependent manner. • Viable controlled delivery of EOS probiotics requires redesigned bioencapsulation and anaerobic processing strategies.
Keywords:
Bioencapsulation
Anaerobutyricum hallii
Lactobacillus johnsonii
Prilling
Extremely oxygen-sensitive probiotics
Hydrogel microcomposites
Probiotic viability
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