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Oxygen exposure and diffusion are key formulation barriers in the microencapsulation of extremely oxygen-sensitive next-generation probiotics

delete2026-07-27
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OA
AI
Y
Yijia Zhong
H
Harry J. Harvey
S
Sarah Corrigan
P
Phuong Linh Ta
K
Kele Shen
N
Nneka W. Igwebuike
L
Liam M. Grover
R
R. D. Horniblow *
DOI:10.1016/j.jconrel.2026.115208delete
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Abstract

Abstract

En 中文
• EOS probiotics are not compatible with conventional aerobic bioencapsulation workflows. • Oxygen exposure during homogenisation, aerosolisation, and cross-linking limits EOS viability. • Calcium exposure imposes an additional non-oxygen stress on EOS recovery. • Alginate microcomposites slow oxygen ingress in a particle-size-dependent manner. • Viable controlled delivery of EOS probiotics requires redesigned bioencapsulation and anaerobic processing strategies.
Keywords:
Bioencapsulation
Anaerobutyricum hallii
Lactobacillus johnsonii
Prilling
Extremely oxygen-sensitive probiotics
Hydrogel microcomposites
Probiotic viability
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Journal

Journal of Controlled Release cover
Journal of Controlled Release
IF:
11.5
Papers:
1.5W
Citations:
7.4W

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I
Institute of Translational Medicine
Scholars:
184
Papers: 70
Citations: 2
Norwich Research Park cover
Norwich Research Park
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103
Papers: 35
Citations: 9.4K
U
university of birmingham
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4.2K
Papers: 2.0K
Citations: 0
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