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P68 Quantitative structure–activity relationship (QSAR) analysis of herpes simplex virus (HSV) thymidine kinase inhibitors: identifying key molecular determinants of antiviral activity
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DOI：10.1093/jacamr/dlag102.074.png)
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Abstract
En 中文
Herpes simplex virus (HSV) infections affect millions globally and remain a significant clinical burden [1]. HSV thymidine kinase is a key antiviral drug target; however, increasing resistance to existing therapies, such as acyclovir, underscores the need for novel inhibitors [2]. Quantitative structure–activity relationship (QSAR) modelling enables the identification of molecular features driving biological activity and supports rational antiviral drug design [3].
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