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PAD2-mediated citrullination of MBP and early myelin destabilization in multiple sclerosis
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DOI：10.1016/j.jaut.2026.103577.png)
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Abstract
En 中文
• PAD2-mediated MBP citrullination is proposed as a candidate early event preceding classic MS lesion formation. • MBP citrullination alters myelin compaction, potentially creating a “prelesional” state in the Normal Appearing White Matter (NAWM). • Aberrant citrullination may bridge the gap between structural myelin damage and T-cell mediated autoimmunity via specific HLA-DRB1 binding. • Understanding the PAD2/MBP axis offers a novel hypothesis for early-stage therapeutic intervention and remyelination strategies.
Keywords:
Post-translational modifications
Multiple sclerosis
Myelin
Myelin basic protein
Autoimmunity
Demyelination
Remyelination
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