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Paired pre- and post-transplant human immunoprofiling identifies an IFN-γ-JAK1 axis limiting stem-cell-derived RPE engraftment

delete2026-06-17
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PRE
AI
J
Junfeng Ma
L
Lifu Zhu
P
Ping Duan
T
Tao Ding
Z
Zhenghang Cheng
B
Bin Li
Q
Qingfeng Wang
X
Xiang Ma
Y
Youcai Deng
D
Deepak A. Lamba
Y
Yuan Gao *
DOI：10.1016/j.stem.2026.05.006delete
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Abstract

Abstract

En 中文
• A Th1-biased, IFN-γ-rich immune state defines hESC-RPE graft vulnerability • IFN-γ-JAK1 signaling drives immunogenic reprogramming of hESC-RPE • Ex vivo ruxolitinib dampens IFN-γ-JAK-STAT activation and HLA induction • Humanized models show reduced T/NK infiltration, prolonged survival, and visual benefit

Journal

Cell Stem Cell cover
Cell Stem Cell
IF:
20.4
Papers:
3.6K
Citations:
3.1W

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A
army medical university
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Chongqing Medical University
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key lab of visual damage and regeneration and restoration of chongqing
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Genentech
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nanjing medical university
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