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Palladium-Catalyzed Four-Component Tandem Sulfonylation and Carbonylation of 1,6-Enynes
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AI
王
王
X
J
DOI：10.1002/adsc.70226.png)
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Abstract
En 中文
A novel palladium-catalyzed four-component tandem sulfonylation and carbonylation of 1,6-enynes has been developed for the rapid construction of succinimide, sulfone, and carbonyl motifs simultaneously. In the presence of very low palladium catalyst loading, the reaction of 1,6-enynes with nucleophiles proceeded smoothly to afford a wide range of sulfone- and carbonyl-containing succinimide derivatives with high yields and excellent selectivity. Notably, modifications of bioactive molecules were also demonstrated by using this method.
Keywords:
1,6-enynes
carbonylation
functionalized succinimides
sulfonylation
tandem reactions
Journal
A
IF:
4
Papers:
1.0W
Citations:
2.6W
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Cited Papers