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Pantheon-DNA: Versatile encoding-decoding system with integrated adaptive NGS preprocessing algorithms for DNA data storage
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DOI：10.1016/j.csbj.2025.09.002.png)
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Abstract
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• Pantheon-DNA integrates adaptive NGS preprocessing with a robust encoding-decoding codec. • Modular pipeline: Chiron (demultiplexing), Hermes (addressing), Hephaestus (clustering). • Achieves ≥99.996% retrievability at 10× coverage under LER and HER in our tests. • Delivers faster decoding while reserving MSA for cases that require it, reducing computational time. • Scales to 90 MB in silico and is validated by a 1.59 MB synthesis-–sequencing experiment.
Keywords:
DNA data storage
Sequencing data preprocessing
Encoding schemes
Software engineering
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