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Paraproteinemias in Sjögren disease: cryoglobulinemia and serum monoclonal gammopathy identify distinct clinical phenotypes and differential lymphoma susceptibility
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DOI：10.1016/j.semarthrit.2026.152986.png)
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Abstract
En 中文
• Isolated detectable serum monoclonal gammopathy, cryoglobulinemia, and their coexistence delineate distinct phenotypic subsets in Sjögren disease (SjD). • Cryoglobulinemia is linked with a predominant vasculitic phenotype. • The combination of cryoglobulinemia and monoclonal gammopathy is linked with high lymphoproliferative activity and lymphoma susceptibility. • SjD patients with both serum detectable monoclonal gammopathy and cryoglobulinemia require careful monitoring due to increased lymphoma risk.
Keywords:
Cryoglobulinemia
Monoclonal gammopathy
Lymphoma
Sjögren disease
B cells
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