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Partial agonists go molecular
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DOI：10.1016/j.tips.2021.04.008.png)
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Abstract
En 中文
Single-channel analysis previously revealed a key role for a shortlived 'flipped' state during glycine receptor activation by partial agonists. Structures solved by Yu and colleagues now reveal a surprising mechanism involving a partially activated agonist-bound closed state that is too long-lived to be considered the flipped state.
Keywords:
RECEPTOR
MECHANISM
MUSCLE
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