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Pathological and Perioperative Outcomes of Conversion Hepatectomy After Contemporary Combination Downstaging for Initially Unresectable Hepatocellular Carcinoma: A Systematic Review
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DOI：10.3390/curroncol33080453.png)
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Abstract
En 中文
For some patients with advanced hepatocellular carcinoma, modern drug combinations and locoregional therapies can shrink or biologically control the tumor enough to make liver surgery possible. This review examined what happens after those patients actually reach hepatectomy. Across the available studies, surgeons often achieved complete tumor removal, and a meaningful proportion of patients had no viable tumor left in the resected specimen. However, the evidence comes mostly from retrospective, highly selected cohorts treated in experienced East Asian centers, and important surgical details were not reported consistently. These findings suggest that conversion hepatectomy is promising for carefully chosen patients, but stronger prospective studies with standardized reporting are still needed before the approach can be broadly standardized.
Keywords:
hepatocellular carcinoma
liver resection
conversion therapy
downstaging
hepatectomy
salvage surgery
immunotherapy
tyrosine kinase inhibitor
pathological complete response
perioperative outcomes
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