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Patient-derived forebrain cortical organoids reveal biphasic tau–MAP6–microtubule axis dysfunction in tauopathy
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DOI：10.1002/alz.71565.png)
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Abstract
En 中文
In frontotemporal dementia (FTD), tau detaches from axonal microtubules and forms pathological aggregates. Rather than stabilizing microtubules, tau promotes labile microtubule domains, redefining its role in neurodegeneration and underscoring the need for human models that capture temporal disease progression.
Keywords:
cortical organoids
MAP6
microtubule
tau
tauopathy
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