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Patterned cell and matrix dynamics in branching morphogenesis
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DOI：10.1083/jcb.201610048.png)
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Abstract
En 中文
Many embryonic organs undergo branching morphogenesis to maximize their functional epithelial surface area. Branching morphogenesis requires the coordinated interplay of multiple types of cells with the extracellular matrix (ECM). During branching morphogenesis, new branches form by budding or clefting. Cell migration, proliferation, rearrangement, deformation, and ECM dynamics have varied roles in driving budding versus clefting in different organs. Elongation of the newly formed branch and final maturation of the tip involve cellular mechanisms that include cell elongation, intercalation, convergent extension, proliferation, and differentiation. New methodologies such as high-resolution live imaging, tension sensors, and force-mapping techniques are providing exciting new opportunities for future research into branching morphogenesis.
Keywords:
EPITHELIUM IN-VITRO
PLANE ILLUMINATION MICROSCOPY
SUPERNUMERARY TRACHEAL BUDS
MAMMARY-GLAND DEVELOPMENT
BIOENGINEERED ORGAN GERM
URETERAL BUD
LUNG DEVELOPMENT
SUBMANDIBULAR-GLAND
BASEMENT-MEMBRANE
BLOOD-VESSELS
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