.png){kind=icon}
.png){kind=icon}
Return
PCSK9 promotes aging-related cardiac calcification by inducing osteogenic differentiation of cardiac fibroblasts
.png){kind=icon}
PRE
AI
G
Q
L
B
C
S
Y
C
C
X
DOI：10.1016/j.mad.2026.112215.png)
.png){kind=icon}
Original request for help.png){kind=icon}
Share.png){kind=icon}
Save
Abstract
En 中文
• Aging is associated with cardiac calcification and upregulation of osteogenic markers in the heart. • PCSK9 expression is increased in aged hearts and is enriched in DDR2‑positive interstitial cells. • PCSK9‑mediated osteogenic differentiation in cardiac fibroblasts is linked to ATF4‑dependent Runx2 upregulation.
Keywords:
ALP
,
alkaline phosphatase
CFs
,
cardiac fibroblasts
DDR2
,
discoidin domain receptor 2
ER stress
,
endoplasmic reticulum stress
LDLR
,
low-density lipoprotein receptor
LDL-C
,
low-density lipoprotein cholesterol
LVEF
,
left ventricular ejection fraction
LVFS
,
left ventricular fractional shortening
LVIDd
,
left ventricular internal diameter at diastole
LVIDs
,
left ventricular internal diameter at systole
OCN
,
osteocalcin
Osx
,
osterix
PCSK9
,
proprotein convertase subtilisin/kexin type 9
ROS
,
reactive oxygen species
Runx2
,
runt-related transcription factor 2
SREBP2
,
sterol regulatory element-binding protein 2
PCSK9
cardiac calcification
cardiac fibroblasts
osteogenic differentiation
Journal
IF:
5.1
Papers:
3.2K
Citations:
7.8K
Organization
Cited Papers