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PD-1 blockade unleashes local hepatitis B virus-related B cell response inhibiting hepatocellular carcinoma

delete2026-07-16
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PRE
AI
S
Shuling Chen *
Y
Yuanqi Wang
J
Jingying Chen
W
Wenxuan Xie
J
Jianyu Chen
G
Guanrui Liao
X
Xiaoxue Ren
K
Kai Lei
Y
Yuting Zhang
S
Shu Wang
Y
Ye Yang
Y
Youmei Kang
Q
Qiaoyi Chen
Y
Yixi Wen
J
Jiaming Lai
P
Pengyuan Yang
S
Shunli Shen
S
Shaoqiang Li
J
Johnson Yiu-Nam Lau
C
Changjun Yin *
DOI：10.1016/j.ccell.2026.06.010delete
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Abstract

Abstract

En 中文
• Anti-PD-1 therapy unleashes local B cell response targeting Hepatitis B core antigen • Extracellular HBcAg is a tumor hallmark in resectable HBV-related HCCs • Developed a method to visualize antibody affinity enhancement within tumor TLSs in situ • Anti-HBcAg enhanced anti-PD-1 therapy efficacy via C1q-dependent mechanism in HCC

Journal

Cancer Cell cover
Cancer Cell
IF:
44.5
Papers:
413
Citations:
5.6W

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