PDE4A Knockdown Rescues Alcohol-Induced Cognitive Impairment and Synaptic Dysfunction via the cAMP/PKA/CREB Pathway

doi:10.1093/ijnp/pyag031

PDE4A Knockdown Rescues Alcohol-Induced Cognitive Impairment and Synaptic Dysfunction via the cAMP/PKA/CREB Pathway

2026-07-11

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Han-Ting Zhang, PhD *

DOI：10.1093/ijnp/pyag031

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Alcoholic dementia (AlD) is a severe neurological disorder with no effective treatment. Development of pan-phosphodiesterase-4 (PDE4) inhibitors for clinical treatment of neurological conditions has been hampered by emetic side effects primarily mediated by PDE4D, one of the four subtypes of PDE4. Although PDE4A was shown to be upregulated by chronic alcohol exposure, its therapeutic relevance to AlD remains unclear.

PDE4A Knockdown Rescues Alcohol-Induced Cognitive Impairment and Synaptic Dysfunction via the cAMP/PKA/CREB Pathway

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