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PDK1 Downregulation Impairs Decidualization via Dysregulated Glycolysis: Potential Relevance to Preeclampsia

delete2026-04-06
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PRE
AI
Y
Yutong Liu
H
Hua Li
L
Liang Zhang
J
Jing Tong
H
Huiyu Liu
X
Xingyu Yan
L
Lisheng Liu *
C
Cong Zhang *
DOI：10.1016/j.mce.2026.112803delete
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Abstract

Abstract

En 中文
• PDK1 is downregulated in decidual tissues from severe preeclampsia patients • PDK1 promotes decidualization by enhancing glycolysis in endometrial stromal cells • PDK1 knockdown impairs decidualization and trophoblast invasion in vitro • PDK1 increases during mouse decidualization independent of embryonic signals
Keywords:
PDK1
decidualization
glycolysis
preeclampsia
endometrial stromal cells

Journal

Molecular and Cellular Endocrinology cover
Molecular and Cellular Endocrinology
IF:
3.6
Papers:
8.0K
Citations:
1.6W

Organization

S
shanghai jiao tong university
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15.1W
Papers: 11.5W
Citations: 159
S
Shandong Normal University
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1.6K
Papers: 557
Citations: 1.2W
J
jinan maternity and child care hospital
Scholars:
6
Papers: 2
Citations: 0
S
Shandong First Medical University and Shandong Academy of Medical Sciences
Scholars:
1.4K
Papers: 491
Citations: 105
S
shandong first medical university
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1.1K
Papers: 434
Citations: 1
N
nankai university
Scholars:
4.6W
Papers: 3.2W
Citations: 74
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