PepHarmony: a multi-view contrastive learning framework for integrated sequence and structure-based peptide representation

doi:10.1016/j.neunet.2025.108148

PepHarmony: a multi-view contrastive learning framework for integrated sequence and structure-based peptide representation

2025-09-23

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周丰丰 (Fengfeng Zhou) *

高

高欣 (Xin Gao) *

DOI：10.1016/j.neunet.2025.108148

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Recent advances in protein language models have catalyzed significant progress in peptide sequence representation. Despite extensive exploration in this field, pre-trained models tailored for peptide-specific needs remain largely unaddressed due to the difficulty in capturing the complex and sometimes unstable structures of peptides. This study introduces a novel multi-view contrastive learning framework PepHarmony for the sequence-based peptide representation task. PepHarmony innovatively combines sequence- and structure-level information into a sequence-level encoding module through contrastive learning. We carefully select datasets from the Protein Data Bank and AlphaFold DB to encompass a broad spectrum of peptide sequences and structures. The experimental data highlights PepHarmony's exceptional capability in capturing the intricate relationship between peptide sequences and structures compared with the baseline and fine-tuned models. The robustness of our model is confirmed through extensive ablation studies, which emphasize the crucial roles of contrastive loss and strategic data sorting in enhancing predictive performance. The training strategies and the pre-trained PepHarmony model serve as helpful contributions to peptide representations, and offer valuable insights for future applications in peptide drug discovery and peptide engineering.

PepHarmony: a multi-view contrastive learning framework for integrated sequence and structure-based peptide representation

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