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Peptide hormone precursor processing: getting sorted?

delete1999-10-01
delete38
PRE
AI
L
Lucie Canaff
H
H.P.J. Bennett
G
Geoffrey N. Hendy *
DOI：10.1016/S0303-7207(99)00129-Xdelete
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Abstract

Abstract

En 中文
Processing of proproteins to biologically active peptides and, in the case of peptide hormones and neuropeptides, their sorting to granules of the regulated secretory pathway, requires the concerted action of a cascade of enzymes and chaperones. The purpose of this review is to summarize the recent emerging knowledge of how these molecules affect specific endocrine systems. This has come about through the study of gene knockout mice as well as endocrinopathies resulting from mutated genes in humans. (C) 1999 Elsevier Science Ireland Ltd. All rights reserved.
Keywords:
proprotein convertase
carboxypeptidase
7B2
granin

Journal

Molecular and Cellular Endocrinology cover
Molecular and Cellular Endocrinology
IF:
3.6
Papers:
8.0K
Citations:
1.6W

Organization

No organization information available