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Per2 deficiency exacerbates IL-17-driven psoriasiform dermatitis in a diurnal-dependent manner

delete2026-03-19
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PRE
AI
L
Lei Zhang
X
Xin Liu
Y
Yan Lin
P
Ping Li
X
Xinran Xie *
DOI：10.1016/j.imlet.2026.107170delete
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Abstract

Abstract

En 中文
• Per2 deficiency exacerbates psoriasiform dermatitis with a nocturnal peak at ZT14. • Loss of Per2 boosts IL-17A/F production by Th17 and γδT cells independently of IL-23. • Per2 functions as a diurnal “molecular gate” for the cutaneous IL-17 effector axis. • Elevated NFIL3 and RORγt drive IL-17 surges, marking NFIL3 as a chronotherapeutic target.
Keywords:
Per2
IL-17
psoriasiform dermatitis
diurnal rhythm
NFIL3

Journal

Immunology Letters cover
Immunology Letters
IF:
2.8
Papers:
4.5K
Citations:
6.1K

Organization

C
Capital Medical University
Scholars:
5.3W
Papers: 3.3W
Citations: 3.2W
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