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Peripheral B cell subsets
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DOI：10.1016/j.coi.2008.03.014.png)
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Abstract
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Our understanding of the origins and the biological functions of different peripheral B cell subsets continues to evolve. Some understanding has been obtained regarding the synergy between BCR-derived signals and other receptors and signaling pathways that drive the development of follicular, marginal zone, and B-1 B cells, but this remains a complex and poorly understood issue. More recent information regarding the origins of B-1 and B-2 B cells, the ability of follicular B cells to mature both in the bone marrow and the spleen, the existence of a definable precursor for MZ B cells, and the ability of follicular B cells to occupy two distinct niches are all highlighted in this review.
Keywords:
TOLL-LIKE RECEPTORS
MARGINAL-ZONE
BONE-MARROW
INDEPENDENT RESPONSES
POSITIVE SELECTION
SURVIVAL SIGNALS
DENDRITIC CELLS
T-CELLS
LYMPHOCYTES
SPLEEN
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