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pH-triggered in situ mineralized NIR-II nanozyme hydrogel enables spatiotemporally controlled antibacterial therapy and microenvironment reprogramming for infected bone defect repair

delete2026-08-03
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PRE
AI
K
Kaiwen Chang
P
Peiyun Lin
K
Ke Xue
M
Mengyao Zou
Z
Zhan Gao
S
Shuoshuo Fu
Y
Ying Bai
S
Sihan Zhang
J
Jinghua Liu
Z
Zhijun Yang *
DOI：10.1016/j.bioadv.2026.215094delete
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Abstract

Abstract

En 中文
• A multifunctional nanozyme hydrogel (GAPCP) is developed for infected bone repair. • NIR-II photothermal therapy achieves rapid and effective bacterial biofilm disruption. • The system alleviates oxidative stress and promotes macrophage M2 polarization. • pH-responsive ion release enables spatiotemporally controlled osteogenic differentiation. • This strategy integrates antibacterial, anti-inflammatory, and osteogenic functions.
Keywords:
Infected bone defect
Photothermal antibacterial
Immunomodulation
Bone regeneration
Multifunctional hydrogel

Journal

Biomaterials Advances cover
Biomaterials Advances
IF:
6
Papers:
1.9K
Citations:
6.0K

Organization

H
Henan Medical University
Scholars:
1.4K
Papers: 311
Citations: 0
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