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Pharmacologic Inhibition of RBBP4/p300-mediated Homologous Recombination Activity Enhances Glioblastoma Sensitivity to Temozolomide

delete2026-05-29
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OA
AI
J
Josephine A Mapunda
D
Daniel J Laverty
F
Faisal Aziz
A
An Le
J
Junita Sangare
L
Lin Zhang
Z
Zachary D Nagel
J
Jarrod B French
J
Jann N Sarkaria
G
Gaspar J Kitange *
DOI：10.1093/noajnl/vdag141delete
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Abstract

Abstract

En 中文
Upstream regulators of the homologous recombination (HR) repair pathway are promising targets for overcoming temozolomide (TMZ) resistance. We investigated whether pharmacologic inhibition of RBBP4/p300-mediated HR activity by CCS1477 or NEO2734 sensitizes GBM to TMZ.

Journal

N
Neuro-Oncology Advances
IF:
4.1
Papers:
1.5K
Citations:
3.2K

Organization

M
mayo clinic
Scholars:
8.0W
Papers: 6.5W
Citations: 84
H
harvard t.h. school of public health
Scholars:
4
Papers: 2
Citations: 0
U
university of minnesota
Scholars:
3.2K
Papers: 1.4K
Citations: 0
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