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Pharmacology, clinical applications, and future perspectives of Ciprofol: A narrative review
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DOI：10.1016/j.jclinane.2026.112275.png)
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Abstract
En 中文
• Ciprofol exhibits linear pharmacokinetics and improved tolerability versus propofol • Less injection pain and hemodynamic impact make it potentially suitable for high-risk patients • Dosing must be individualized, especially in elderly and obese populations • Low drug interaction potential supports use in complex clinical scenarios • Emerging evidence positions ciprofol as a candidate for optimal sedation and anesthesia
Keywords:
Ciprofol
Propofol
Pharmacokinetic
Pharmacodynamic
Anesthesia
Sedation
BIS
,
Bispectral Index
CI
,
confidence interval
CIRI
,
cerebral ischemia-reperfusion injury
ED50
,
median effective dose
ERCP
,
endoscopic retrograde cholangiopancreatography
GABAA
,
γ-aminobutyric acid type A
ICU
,
intensive care unit
PD
,
pharmacodynamic
PK
,
pharmacokinetic
POD
,
postoperative delirium
RCT
,
randomized controlled trial
RR
,
risk ratio
UGT
,
UDP-glucuronosyltransferase.
Journal
IF:
5.1
Papers:
6.7K
Citations:
6.8K
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