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Phase 1 study of intracranial T cell therapy with pemetrexed for refractory brain metastases and glioblastomas

delete2026-08-05
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OA
AI
C
Congcong Li
S
Shuang Wang
X
X.S. Rong
C
Chuxiong Zeng
H
Haiyang Zhao
D
Dazhao Xu
L
Lina Hu
L
Linyao Lu
B
Bo Sun
Y
Yanhua Yuan
X
Xiaoli Wang
X
Xinna Zhou
A
Amy Hobeika
M
Michael A. Morse
G
Guanghui Ma *
L
Li Ren *
李冀豫 cover
李冀豫 (Jiyu Li) *
H
H. Kim Lyerly *
Z
Zhijun Bao *
DOI：10.1016/j.xcrm.2026.102967delete
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Abstract

Abstract

En 中文
• Intracranial T cell therapy shows a manageable safety profile • Preliminary disease control observed in a small early-phase cohort • CSF analyses suggest immune activation and reduced tumor signals
Keywords:
advanced intracranial malignancies
brain metastases
RetroNectin-activated killer cells
intracranial administration
pemetrexed
cell therapy

Journal

Cell Reports Medicine cover
Cell Reports Medicine
IF:
10.6
Papers:
2.2K
Citations:
8.9K

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No organization information available
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