Phase variation: how to create and coordinate population diversity

Marjan W. van der Woude

doi:10.1016/j.mib.2011.01.002

Phase variation: how to create and coordinate population diversity

2011-04-01

141

PRE

AI

M

Marjan W. van der Woude *

DOI：10.1016/j.mib.2011.01.002

Original

Original request for help

Save

Abstract

En 中文

Phase variation yields phenotypic heterogeneity in a clonal population as the result of one of a limited number of known molecular mechanisms. These include slipped strand mispairing, site-specific recombination and epigenetic regulation mediated by DNA methylation. Recently new regulatory variants utilizing these mechanisms have been identified, which is facilitating the identification of additional phase variation events solely from genome sequence analysis. Furthermore, it is becoming increasingly clear that in many cases phase variation control is integrated with regulatory networks and with cellular processes of a growing cell. This review focuses specifically on these recent advances in the understanding of the regulation of phase variation.

Keywords:

UROPATHOGENIC ESCHERICHIA-COLI

EPIGENETIC INHERITANCE

NEISSERIA-GONORRHOEAE

BACTEROIDES-FRAGILIS

ANTIGENIC VARIATION

GENE-EXPRESSION

TYPE-1 FIMBRIAE

DNA METHYLATION

MULTIPLE GENES

MOTILITY

Phase variation: how to create and coordinate population diversity

Abstract

Journal

Organization