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Phenomics: the next challenge

delete2010-11-18
delete997
PRE
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D
David Houle *
D
Diddahally R. Govindaraju
S
Stig W. Omholt
DOI:10.1038/nrg2897delete
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Abstract

Abstract

En 中文
A key goal of biology is to understand phenotypic characteristics, such as health, disease and evolutionary fitness. Phenotypic variation is produced through a complex web of interactions between genotype and environment, and such a 'genotype-phenotype' map is inaccessible without the detailed phenotypic data that allow these interactions to be studied. Despite this need, our ability to characterize phenomes - the full set of phenotypes of an individual - lags behind our ability to characterize genomes. Phenomics should be recognized and pursued as an independent discipline to enable the development and adoption of high-throughput and high-dimensional phenotyping.
Keywords:
CARDIOVASCULAR-DISEASE ENTERPRISES
GENOME-WIDE ASSOCIATION
COMMON GENETIC-VARIANTS
BREAST-CANCER RISK
MAJOR SHAREHOLDERS
NATURAL-SELECTION
SEXUAL SELECTION
COMPLEX DISEASE
HEART
PREDICTION
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Key information extracted from the uploaded paper, including a brief overview, abstract, background, key highlights, visual analysis, and future outlook.

Journal

Nature Reviews Genetics cover
Nature Reviews Genetics
IF:
52
Papers:
4.0K
Citations:
4.3W

Organization

State University System of Florida cover
State University System of Florida
Scholars:
12.7W
Papers: 10.9W
Citations: 130
H
Harvard University
Scholars:
26.5W
Papers: 22.0W
Citations: 28.7W
F
Florida State University
Scholars:
1.1W
Papers: 8.6K
Citations: 2.0W
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