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Phenomics: the next challenge
DOI:10.1038/nrg2897.png)
Abstract
En 中文
A key goal of biology is to understand phenotypic characteristics, such as health, disease and evolutionary fitness. Phenotypic variation is produced through a complex web of interactions between genotype and environment, and such a 'genotype-phenotype' map is inaccessible without the detailed phenotypic data that allow these interactions to be studied. Despite this need, our ability to characterize phenomes - the full set of phenotypes of an individual - lags behind our ability to characterize genomes. Phenomics should be recognized and pursued as an independent discipline to enable the development and adoption of high-throughput and high-dimensional phenotyping.
Keywords:
CARDIOVASCULAR-DISEASE ENTERPRISES
GENOME-WIDE ASSOCIATION
COMMON GENETIC-VARIANTS
BREAST-CANCER RISK
MAJOR SHAREHOLDERS
NATURAL-SELECTION
SEXUAL SELECTION
COMPLEX DISEASE
HEART
PREDICTION
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