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Phosphate transporter OsPHT2;1 regulates Cd accumulation in rice via the regulation of phosphorus homeostasis
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DOI：10.1016/j.plantsci.2026.113279.png)
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Abstract
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• OsPHT2;1 is a Cd-responsive gene that negatively regulates Cd tolerance and grain Cd accumulation in rice. • Knockout of OsPHT2;1 triggers a systemic P-starvation signal mediated by OsPHR2 and OsPHO2 under physiological P conditions. • The intensified shoot-to-root signaling in ospht2;1 mutants coordinates the transcriptional repression of root Cd transporters (OsNRAMP5 and OsHMA3). • Haplotype analysis identified Hap1 as an elite variant of OsPHT2;1 for breeding low-Cd rice without yield penalties.
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