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Photosynthesis-Mimicking Hydrogel Biointerface for Noninvasive Neuromodulation and Tissue Integration
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DOI：10.1002/adfm.75290.png)
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Abstract
En 中文
Controllable wireless electrical stimulation holds great promise for peripheral nerve injury therapy, yet remains hindered by the mismatch between rigid electronics and soft tissues, limitations in spatiotemporal resolution, and charge injection efficiency. Inspired by natural photosynthesis, this study develops an injectable and highly conductive hydrogel biointerface engineered via a cyclic salting-out process. By integrating chlorophyll derivatives and conductive nanomaterials into a gelatin network, this hydrogel biointerface mimics the primary photochemical reaction of photosynthesis: chlorophyll derivatives capture light to generate charge carriers, while conductive nanoparticles facilitate long-range carrier diffusion, establishing a robust wireless photoelectric conversion platform. The hydrogel biointerface delivers stable photocurrent (5–100 nA) to elicit precise neural modulation (10–40 Hz) and record compound muscle action potential (5–50 mV), effectively bridging the signaling gap in injured nerves. Following implantation and localized near-infrared excitation, the hydrogel biointerface demonstrates multifunctional therapeutic efficacy, including enabling immediate functional restoration in early-stage injury, accelerating sciatic nerve repair while mitigating muscle atrophy, and promoting epidermal wound healing. This photosynthesis-inspired strategy offers a versatile, minimally invasive solution for bioelectronic medicine and tissue regeneration.
Keywords:
hydrogel interface
neuromodulation
photosynthesis
tissue integration
wireless electrical stimulation
Journal
IF:
19
Papers:
3.4W
Citations:
32.1W