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Physics-Inspired Generative Models in Medical Imaging

delete2025-05-01
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PRE
AI
D
Dennis Hein
A
Afshin Bozorgpour
D
Dorit Merhof *
王高峰 (Ge Wang)
DOI:10.1146/annurev-bioeng-102723-013922delete
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Abstract

Abstract

En 中文
Physics-inspired generative models (GMs), in particular diffusion models and Poisson flow models, enhance Bayesian methods and promise great utility in medical imaging. This review examines the transformative role of such generative methods. First, a variety of physics-inspired GMs, including denoising diffusion probabilistic models, score-based diffusion models, and Poisson flow generative models (including PFGM++), are revisited, with an emphasis on their accuracy, robustness and acceleration. Then, major applications of physics-inspired GMs in medical imaging are presented, comprising image reconstruction, image generation, and image analysis. Finally, future research directions are brainstormed, including unification of physics-inspired GMs, integration with vision-language models, and potential novel applications of GMs. Since the development of generative methods has been rapid, it is hoped that this review will give peers and learners a timely snapshot of this new family of physics-driven GMs and help capitalize their enormous potential for medical imaging.
Keywords:
physics-inspired generative models
Bayesian theorem
diffusion model
Poisson flow generative model
PFGM plus plus
consistency model
image reconstruction
image analysis
image/data synthesis
medical imaging

Journal

Annual Review of Biomedical Engineering cover
Annual Review of Biomedical Engineering
IF:
9.6
Papers:
482
Citations:
5.6K

Organization

K
KTH Royal Inst Technol
Scholars:
684
Papers: 357
Citations: 97
U
Univ Regensburg
Scholars:
444
Papers: 228
Citations: 63
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