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Physiologically relevant oxygen tensions reshape anticancer responses under oxidative stress-permissive culture conditions

delete2026-07-24
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PRE
AI
M
Magdalena Mielczarek‐Puta
D
Dagmara Otto‐Ślusarczyk *
B
Barbara Żyżyńska‐Granica *
W
Wojciech Graboń
M
Marta Struga
DOI：10.1016/j.freeradbiomed.2026.07.041delete
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Abstract

Abstract

En 中文
• Physiological oxygen tensions profoundly alter anticancer drug responses. • Dihydroartemisinin showed the strongest activity across cancer cell lines. • Hypoxia enhanced apoptosis and oxidative stress induced by DHA. • Lipid peroxidation increased despite largely unchanged GPX4 expression.

Journal

Free Radical Biology and Medicine cover
Free Radical Biology and Medicine
IF:
8.2
Papers:
2.1W
Citations:
5.4W

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