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Piezoelectric g-C3N4/rGO heterojunction remodels the periodontitis immune microenvironment to promote neurovascular–bone coupled osseointegration

delete2026-07-27
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OA
AI
D
Dan Li
Z
Zhen Ai
J
Jinyang Lv
Y
Yijun Zheng
C
Chao Zhang *
DOI:10.1016/j.mtbio.2026.103498delete
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Abstract

Abstract

En 中文
• g-C3N4/rGO piezoelectric hydrogel enables short- and long-term synergistic therapy. • Ultrasound-driven ROS generation provides immediate antibacterial protection. • CN/rGO reprograms macrophage M1-to-M2 polarization via JAK-STAT inhibition. • Immune remodeling drives integrated nerve–vessel–bone coupled regeneration. • CN/rGO + US achieves robust osseointegration in a periodontitis implant model.
Keywords:
Piezoelectric hydrogel
Heterojunction
Immunomodulation
Neurovascular–bone coupling
Osseointegration
Periodontitis
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Materials Today Bio cover
Materials Today Bio
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10.2
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