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PLA2G16 deficiency enhances oxaliplatin sensitivity in colorectal cancer

delete2026-04-23
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PRE
AI
F
Fuxi Yang
H
Huilan Wu
X
Xin Luo
蒋丽萍 cover
蒋丽萍 (Liping Jiang)
H
Huiting Liu
Z
Zhuo Zhang
W
Wei Wu
Z
Zhichun Huang
Z
Zhirong Tan *
J
Jie Pan *
DOI：10.1016/j.tice.2026.103554delete
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Abstract

Abstract

En 中文
• PLA2G16 knockout sensitizes CRC to OXA in vitro and in vivo. • PLA2G16 deficiency is associated with altered autophagy-related markers in response to OXA. • Transcriptomic and lipidomic analyses suggest an association of PLA2G16 with lipid metabolism and autophagy-related pathways. • PLA2G16 may be a potential target for improving oxaliplatin response in CRC.
Keywords:
PLA2G16
oxaliplatin sensitivity
colorectal cancer
autophagy
lipid metabolism

Journal

Tissue and Cell cover
Tissue and Cell
IF:
2.5
Papers:
867
Citations:
4.1K

Organization

C
Central South University
Scholars:
10.0W
Papers: 7.2W
Citations: 10.9W
U
university of south china
Scholars:
1.4W
Papers: 6.8K
Citations: 8
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