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Placental Growth Factor Promotes Endothelial Activation and Inflammatory Remodelling in Pulmonary Hypertension

delete2026-07-01
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OA
AI
M
My Ngoc Ha
R
Raphaël Thuillet
M
Mina Ottaviani
C
Corinne Normand
F
Fabien Robert
M
Maxime Surbier
O
Olivier Sitbon
M
Marc Humbert
A
Athénaïs Boucly
L
Laurent Savale
D
Deborah J Gorth
V
Vanessa Petit
L
Ly Tu
C
Christophe Guignabert *
DOI：10.1093/cvr/cvag147delete
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Abstract

Abstract

En 中文
Pulmonary arterial hypertension (PAH) is a progressive cardiopulmonary disorder marked by pulmonary vascular remodelling and vessel loss, paradoxically occurring despite high VEGF signaling. While VEGF/VEGFR pathways are implicated in disease pathogenesis, their role in endothelial and immune cell crosstalk remains poorly understood. Placental growth factor (PlGF), a VEGF family member that selectively binds VEGFR-1, exerts pro-inflammatory effects in other pathological contexts, but its contribution to PAH pathophysiology is unclear. This study explored the contribution of PlGF to endothelial activation and immune-mediated vascular remodelling in PAH.

Journal

Cardiovascular Research cover
Cardiovascular Research
IF:
13.3
Papers:
1.2W
Citations:
2.8W

Organization

I
Inserm
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658
Papers: 232
Citations: 0
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