.png){kind=icon}
.png){kind=icon}
Return
Plasma membrane tension regulates eisosome structure and function
.png){kind=icon}
OA
AI
DOI：10.1091/mbc.E19-04-0218.png)
.png){kind=icon}
.png){kind=icon}
Share.png){kind=icon}
Save
Abstract
En 中文
Eisosomes are membrane furrows at the cell surface of yeast that have been shown to function in two seemingly distinct pathways, membrane stress response and regulation of nutrient transporters. We found that many stress conditions affect both of these pathways by changing plasma membrane tension and thus the morphology and composition of eisosomes. For example, alkaline stress causes swelling of the cell and an endocytic response, which together increase membrane tension, thereby flattening the eisosomes. The flattened eisosomes affect membrane stress pathways and release nutrient transporters, which aids in their down-regulation. In contrast, glucose starvation or hyperosmotic shock causes cell shrinking, which results in membrane slack and the deepening of eisosomes. Deepened eisosomes are able to trap nutrient transporters and protect them from rapid endocytosis. Therefore, eisosomes seem to coordinate the regulation of both membrane tension and nutrient transporter stability.
Keywords:
SACCHAROMYCES-CEREVISIAE
SLM PROTEINS
KINASE YPK1
YEAST
ORGANIZATION
ENDOCYTOSIS
TORC2
UBIQUITINATION
MICRODOMAINS
ACTIVATION
AI Summary
Key information extracted from the uploaded paper, including a brief overview, abstract, background, key highlights, visual analysis, and future outlook.
Journal
IF:
2.7
Papers:
1.0W
Citations:
2.4W