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Plasma microRNA predict cognitive decline in Parkinson’s disease.
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DOI：10.1016/j.parkreldis.2025.108149.png)
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Abstract
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• Plasma microRNA alter with increasing cognitive decline in Parkinson’s disease • Overall direction of change in plasma moves towards downregulation • A notable exception was miR-192-5p which was consistently upregulated • microRNA identified are largely distinct from those related to Alzheimer’s disease • miR-151-3p and miR-192-5p provide the best predictive model for cognitive decline.
Keywords:
Parkinson’s disease
blood-based biomarkers
microRNA
Mild cognitive impairment
Montreal Cognitive Assessment
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