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Polθ helicase: drive or reverse
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DOI：10.1038/nsmb.3510.png)
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Abstract
En 中文
The helicase intrinsic to DNA polymerase theta (Pol theta), the versatile mediator of microhomology-based repair of DNA double-strand breaks and stalled replication forks, is now revealed to be a member of an elite group of proteins known as annealing helicases. This small family of enzymes remodels DNA intermediates in multiple repair processes that are crucial to preserving genome stability and warding off cancer and aging.
Keywords:
DNA-POLYMERASE THETA
STRAND BREAK REPAIR
RECOMBINATION
MECHANISM
PATHWAY
TUMORS
CELLS
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