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Polarimetric total internal reflection biosensing

delete2011-04-04
delete16
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OA
AI
M
Mathieu Maisonneuve *
I
In‐Hyouk Song
S
Sergiy Patskovsky
M
Michel Meunier
DOI：10.1364/OE.19.007410delete
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Abstract

Abstract

En 中文
In this paper, a concept of polarimetric total internal reflection (TIR) biosensor based on the method of temporal phase modulation is presented. Measurements of the phase difference between s- and p-polarized light combined with their amplitudes allow simultaneous detection of the bulk refractive index and thickness of the surface biofilms. Obtained experimental sensitivity is better than 10(-5) in terms of refractive index unit and 0.5 nm in biolayer thickness. Relatively simple technological implementation of the TIR sensors on the base of inexpensive and transparent substrates opens a number of novel applications in biosensing and microscopy. (C)2011 Optical Society of America

Journal

Optics Express cover
Optics Express
IF:
3.3
Papers:
6.1W
Citations:
14.3W

Organization

No organization information available