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Poly(L-selenomethionine) Hydrogel Reprograming Microenvironments for Full-Thickness Diabetic Chronic Wound Repair
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DOI：10.1007/s40242-026-6145-6.png)
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Abstract
En 中文
Full-thickness repair of chronic wounds poses significant clinical challenges. Although antioxidant and anti-inflammatory effects accelerate the healing of chronic wounds, achieving complete skin regeneration with appendages remains challenging in clinical practice. Herein, a unique selenium-containing thermo-sensitive hydrogel, poly(ethylene glycol)-block-poly(L-selenomethionine) (EG45SeMet25), is designed to reprogram the wound microenvironments and promote skin appendage regeneration in diabetic chronic wounds. EG45SeMet25 forms an injectable sol at room temperature and undergoes a sol-gel transition at body temperature, enabling complete filling of irregular wound defects. Moreover, EG45SeMet25 enhances cell proliferation and effectively scavenges intracellular reactive oxygen species (ROS), thereby exerting cytoprotective effects. Meanwhile, it modulates macrophage polarization to establish a pro-regenerative immune microenvironment. EG45SeMet25 significantly promotes the healing of full-thickness skin wounds in diabetic mice. After 14 d, the remaining unhealed wound area decreases to 2.53% of that in the Control group, accompanied by accelerated angiogenesis and a significant increase in skin appendage formation. In summary, EG45SeMet25 is a promising antioxidant organic selenium hydrogel that not only interrupts the “ROS-inflammation” cycle but also enables functional full-thickness skin repair, offering a unique strategy for treating chronic wounds.
Keywords:
Selenium-containing hydrogel
Reactive oxygen species scavenging
Microenvironment reprogramming
Skin appendage regeneration
Diabetic chronic wound
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