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Poly(oligonucleotide)
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DOI：10.1021/ja503142s.png)
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Abstract
En 中文
Here we report the preparation of poly(oligonucleotide) brush polymers and amphiphilic brush copolymers from nucleic acid monomers via graft-through polymerization. We describe the polymerization of PNA-norbornyl monomers to yield poly-PNA (poly(peptide nucleic acid)) via ring-opening metathesis polymerization (ROMP) with the initiator, (IMesH(2))-(C5H5N)(2)(Cl)(2)RuCHPh.(1) In addition, we present the preparation of poly-PNA nanopartides from amphiphilic block copolymers and describe their hybridization to a complementary single-stranded DNA (ssDNA) oligonucleotide.
Keywords:
CONTROLLED RADICAL POLYMERIZATION
SYNTHETIC-POLYMERS
STRAND DISPLACEMENT
BLOCK-COPOLYMERS
GRAFTING-FROM
FOLDING DNA
PEPTIDE
RECOGNITION
PROTEIN
INITIATORS
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15.6
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60.2W
