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Polyamines and Autophagy as a Dynamic Regulatory Network in Skeletal Muscle Regeneration and Aging
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DOI：10.1016/j.mad.2026.112188.png)
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Abstract
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• Autophagy is central to muscle health and declines with aging. • Spermidine counteracts aging by activating autophagy and extending lifespan. • Polyamine metabolism is activated during muscle regeneration and differentiation. • SMOX levels are elevated in healthy muscle and decreased in atrophic muscle. • Spermidine and exercise show synergistic anti-atrophic effects.
Keywords:
Autophagy
Polyamines
Muscle regeneration
Aging
Spermidine
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